Faculty Profile

Emery Bresnick
4009 WIMR, 1111 Highland Avenue
(608) 265-64456
Training Programs & Grants
Research Description
We use multidisciplinary approaches to understand important biological processes, including stem/progenitor cell function, normal and malignant blood cell development (hematopoiesis), vascular biology, and epigenetics. Such approaches include genomics, proteomics, chemical genetics, and computational analysis, as well as traditional molecular, cellular, and biochemical technologies. A major effort involves discovering mechanisms governing the genesis and function of hematopoietic stem and progenitor cells in normal and disease states. Such mechanisms broadly inform developmental biology, fundamental aspects of cell/molecular biology, and translational/clinical science. Another program focuses on the transcriptional/epigenetic control of red blood cell development and function. These genomic/epigenomic studies address how chromatin modification/remodeling control ensembles of endogenous loci in a cell type-specific manner and yield principles of genome science.
Selected Publications
• DeVilbiss, A, Boyer ME, and Bresnick EH. Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators. Proc Natl Acad Sci USA 110: 3398-407, 2013. PMCID: PMC3767509
• Gao, X, Johnson, KD, Chang, Y-I, Zhang, J, and Bresnick, EH. Gata2 cis-element requirement for hematopoietic stem cell generation in the mammalian embryo. J Exp Med 210: 2833-42, 2013. PMCID: PMC3865483