Faculty Profile

Alan Attie
543A Biochemistry Addition, 433 Babcock Dr
(608) 262-1372
Training Programs
Research Description
Our lab studies genes and pathways that contribute to obesity and diabetes. We take advantage of Mendelian randomization to find genes that are causal for disease phenotypes. By genetically mapping a multitude of phenotypes (e.g. physiology, transcriptomics, epigenomic marks, microbiome), we are able to identify phenotypes that are in pathways leading to disease.
Selected Publications
• Bhatnagar, S. Oler, A.T., Rabaglia, M.E., Stapleton, D.S., Schueler, K.L., Truchan, N.A., Worzella, S.L., Stoehr, J.P., Clee, S.M., Yandell, B.S., Keller, M.P., Thurmond, D.C., and Attie, A.D. (2011) Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn 2, a Negative Regulator of Insulin Secretion. PLoS Genetics 7,e1002323. PMID: 21998599
• Kebede, M.A., Oler, A.T., Gregg, T., Balloon, A.J., Johson, K. Mitok, A., Rabaglia, M., Schueler, K., Stapleton, D., Thorstenson, C., Wrighton, L., Floyd, B.J., Richards, O., Eliceiri, K., Seidah, N.H., Rhodes, C., Keller, M.P., Coon, J.L., Audya, A., Attie, A.D. (2014) Sorcs1 is necessary for normal dense core vesicle biogenesis in metabolically stress beta-cells. J. Clin. Invest. 124,4240-4256. PMID: 25157818